Expression and significance of hypoxia-inducible factor-1 alpha and MDR1/P-glycoprotein in human colon carcinoma tissue and cells
作者： Zhenyu Ding , Li Yang , Xiaodong Xie , Fangwei Xie , Feng Pan
DOI: 10.1007/S00432-010-0828-5
关键词:
摘要: Purpose Hypoxia in tumors is generally associated with chemoresistance and radioresistance. However, the correlation between heterodimeric hypoxia-inducible factor-1 (HIF-1) multidrug resistance (MDR1) gene/transporter P-glycoprotein (P-gp) has not been clearly investigated. This study aims at examining expression levels of HIF-1α MDR1/P-gp human colon carcinoma tissues cell lines (HCT-116, HT-29, LoVo, SW480) ascertaining whether plays an important role tumor MDR1/P-gp.
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