Sequence analysis of the RNA polymerase gene of foot-and-mouth disease virus serotype Asia1.
作者： George Manju , Venkataramanan Ramamurthy , Pattnaik Bramhadev , Sanyal Aniket , CB Gurumurthy
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摘要: The complete nucleotide (nt.) sequence of the RNA polymerase (3D) gene and 81 nt. in 3′-untranslated region foot-and-mouth disease virus (FMDV) serotype Asia1 (IND63/72) was determined compared with other FMDV serotypes. 3D genomic 1410 long encoding 470 amino acids an inframe stop codon (TAA) at position 1411–1413. deduced acid protein showed 8 conserved motifs as reported picornaviruses, 2 which are 100% identical across Antigenic regions were predicted found to be located N-terminus protein. phylogenetic analysis that FMD viruses segregated into different clusters based on geographical origin; did not cluster tightly any groups.
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