Pancreatic Cancer Genetics

摘要: Cancer of the pancreas is fourth leading cause death by cancer in Western countries. In France, 7,200 persons die from this disease every year and more than 70,000 Europe; USA, annual rate about 30,000. With an incidence/death ratio 0.99, pancreatic a crucial public health issue. Although perioperative radiation therapy chemotherapy can be slightly advantageous terms survival, they have no proven effect on prognosis. Surgery offers only possible cure if resection margins remain healthy. But 10–15% patients localized resectable tumors at diagnosis most operated rapidly develop locoregional or metastatic progression. Screening for cancer, which could result early thus increase chances curative treatment, not currently available. There known biological clinical screening test with efficacy risk factors associated sporadic forms are unknown. Thus, tumor has very poor A better understanding mechanisms development probably contribute to identification new molecular targets improvement treatment. large body work been devoted genetic alterations their role cancer.