Relationship of p53 Overexpression and Up-Regulation of Proliferating Cell Nuclear Antigen with the Clinical Course of Non-Small Cell Lung Cancer

摘要: p53 is known to play a central role in the control of cell proliferation and carcinogenesis. In non-small lung cancer, however, clinicopathological studies have yielded conflicting results. current study, we examined 123 cancers with detailed clinical information, 71 primary 52 metastatic tumors, using formalin-fixed paraffin-embedded surgical specimens show correlation immunohistochemical (DO-7) overexpression p53. Nuclear specific appeared 48 (39%; any number tumor cells positive) tumors (35% 44% tumors). The distribution intensity staining were variable. Ninety-eight % all also expressed nuclear immunoreactivity for proliferating antigen (PCNA; PC 10) varying degree. univariate analysis, both (>10% positive; n = 11) PCNA (>50% 32) associated shorter survival curative intent group (stages I, II, IIIA) 63 patients. multivariate analysis including variables, (but not PCNA) was found be an independent prognostic factor ( P 2 0.0011) group. No detected between immunoreactivities patient characteristics, such as age, gender, or smoking. Double immunohistochemistry revealed distinct pattern, whereas its remained elusive. We conclude that cancer independently shortened may significance selected patients earlier stage cancer.