A Potential Role for Mononuclear Phagocytes in Cutaneous Ulcer Development in Human Immunodeficiency Virus-Leishmania braziliensis Coinfection
作者： Luiz H. Guimarães , Alex Torres , Sara Passos , Lucas P. Carvalho , Maíra Saldanha
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摘要: Abstract Skin ulcer development in cutaneous leishmaniasis due to Leishmania braziliensis infection is associated with a mononuclear cell infiltrate and high levels of tumor necrosis factor (TNF). Herein, we show that despite the absence Leishmania-driven TNF, patient acquired immunodeficiency syndrome developed skin ulcer. The presence phagocytes chemokine (C-C motif) ligand 2 (CCL2), metalloproteinase-9 tissue are identified as potential contributors immunopathology observed L. braziliensis-infected patients.
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