Effect of Pioglitazone on Perihematomal Edema in Intracerebral Hemorrhage Mouse Model by Regulating NLRP3 Expression and Energy Metabolism.

摘要: OBJECTIVE Cerebral edema is the predominant mechanism of secondary inflammation after intracerebral hemorrhage (ICH). Pioglitazone, peroxisome proliferator-activated receptor gamma agonist has been shown to play a role in regulation central nervous system inflammation. Here, we examined pharmacological effects pioglitazone an ICH mouse model and investigated its on NLRP3 inflammasome glucose metabolism. METHODS The was established C57 BL/6 mice by stereotactical inoculation blood (30 µL) into right frontal lobe. treatment group administered i.p. (20 mg/kg) for 1, 3, 6 days. control phosphate-buffered saline We brain water contents, expression, changes metabolites using liquid chromatography-tandem mass spectrometry. RESULTS On day treated with decreased more than that group. Expression levels were those days 3 7. showed higher glycolytic mice. Lactate production increased pioglitazone. CONCLUSION Our results demonstrated less swelling following Pioglitazone NLRP3-related anaerobic glycolysis, resulting lactate model. might be therapeutic target recovery.