ALG3 contributes to the malignant properties of OSCC cells by regulating CDK-Cyclin pathway.
作者： Peihong Shao , Chengshi Wei , Yun Wang
DOI: 10.1111/ODI.13687
关键词:
摘要: In this study, we planned to investigate the function and potential mechanisms of Alpha-1,3-mannosyltransferase (ALG3) in oral squamous cell carcinoma (OSCC). Data from TCGA were used analyze ALG3 expression its effect on prognosis patients with OSCC. KEGG enrichment analysis was applied explore pathways related ALG3. measured by qPCR Western blot. Cell counting kit-8, colony formation, transwell assays implemented detect effects malignant biological properties OSCC cells. The key proteins CDK-Cyclin pathway detected samples higher than that control samples, increase unfavorable patients. Additionally, elevated associated pathological stage, lymph node metastasis, primary lesion depletion blocked growth movement cells, while over-expression reversed these phenomena. Moreover, exhaustion resulted decreased MCM7/CCNB2/CDK1/PCNA, phenomena inversed after up-regulation. enhancement promoted aggressive behaviors cells probably promoting pathway.
scilit.net参考文章(32)
Yolanda Espinosa Parrilla, Xavier Munoz, Catalina Bonet, Nadia Garcia, Adoracion Venceslà, Nikos Yiannakouris, Alessio Naccarati, Sabina Sieri, Salvatore Panico, José M Huerta, Aurelio Barricarte, Virginia Menéndez, Emilio Sanchez Cantalejo, Miren Dorronsoro, Paul Brennan, Talita Duarte Salles, H Bas Bueno de Mesquita, Elisabete Weiderpass, Eiliv Lund, Francoise Clavel Chapelon, Marie Christine Boutron Ruault, Antoine Racine, Mattijs E Numans, Rosario Tumino, Federico Canzian, Daniele Campa, Malin Sund, Mattias Johansson, Bodil Ohlsson, Bjorn Lindkvist, Kim Overvad, Anne Tjonneland, Domenico Palli, Ruth C Travis, Kay Tee Khaw, Nick Wareham, Heiner Boeing, Gabriella Nesi, Elio Riboli, Carlos A Gonzalez, Nuria Sala, None, Genetic association of gastric cancer with miRNA clusters including the cancer-related genes MIR29, MIR25, MIR93 and MIR106 : Results from the EPIC-EURGAST study International Journal of Cancer. ,vol. 135, pp. 2065- 2076 ,(2014) , 10.1002/IJC.28850
Z.-Z. Shi, Y.-Y. Jiang, J.-J. Hao, Y. Zhang, T.-T. Zhang, L. Shang, S.-G. Liu, F. Shi, M.-R. Wang, Identification of putative target genes for amplification within 11q13.2 and 3q27.1 in esophageal squamous cell carcinoma. Clinical & Translational Oncology. ,vol. 16, pp. 606- 615 ,(2014) , 10.1007/S12094-013-1124-Z
Gangli Liu, Pritam K. Sengupta, Basem Jamal, Hsiao-Ying Yang, Meghan P. Bouchie, Volkhard Lindner, Xaralabos Varelas, Maria A. Kukuruzinska, N-glycosylation induces the CTHRC1 protein and drives oral cancer cell migration. Journal of Biological Chemistry. ,vol. 288, pp. 20217- 20227 ,(2013) , 10.1074/JBC.M113.473785
George A. Khoury, Richard C. Baliban, Christodoulos A. Floudas, Proteome-wide post-translational modification statistics: frequency analysis and curation of the swiss-prot database Scientific Reports. ,vol. 1, pp. 90- ,(2011) , 10.1038/SREP00090
Donald W Kufe, None, Mucins in cancer: function, prognosis and therapy. Nature Reviews Cancer. ,vol. 9, pp. 874- 885 ,(2009) , 10.1038/NRC2761
Song Fan, Qiong‐lan Tang, Ying‐jin Lin, Wei‐liang Chen, Jin‐song Li, Zhi‐quan Huang, Zhao‐hui Yang, You‐yuan Wang, Da‐ming Zhang, Hui‐jing Wang, Eduardo Dias‐Ribeiro, Qiang Cai, Lei Wang, A review of clinical and histological parameters associated with contralateral neck metastases in oral squamous cell carcinoma. International Journal of Oral Science. ,vol. 3, pp. 180- 191 ,(2011) , 10.4248/IJOS11068
Prashanta Shrestha, Kazuto Yamada, Tomio Wada, Shigenari Maeda, Masahiro Watatani, Masayuki Yasutomi, Hitoshi Takagi, Masahiko Mori, Proliferating cell nuclear antigen in breast lesions: correlation of c-erbB-2 oncoprotein and EGF receptor and its clinicopathological significance in breast cancer. Virchows Archiv. ,vol. 421, pp. 193- 202 ,(1992) , 10.1007/BF01611175
Shinogu Takashima, Hajime Saito, Naoko Takahashi, Kazuhiro Imai, Satoshi Kudo, Maiko Atari, Yoshitaro Saito, Satoru Motoyama, Yoshihiro Minamiya, Strong expression of cyclin B2 mRNA correlates with a poor prognosis in patients with non-small cell lung cancer Tumor Biology. ,vol. 35, pp. 4257- 4265 ,(2014) , 10.1007/S13277-013-1556-7
H.N. LEE, Y.W. KIM, T.C. PARK, D.Y. RO, J.C. SHIN, S.J. SHIN, J.-S. SEO, W.S. AHN, Y.-W. CHOI, S.M. BAE, Y.-W. KIM, Gene expression profiles in squamous cell cervical carcinoma using array‐based comparative genomic hybridization analysis International Journal of Gynecological Cancer. ,vol. 17, pp. 687- 696 ,(2007) , 10.1111/J.1525-1438.2007.00834.X
Ibrahim F. Al-Sheneber, Henry R. Shibata, John Sampalis, Serge Jothy, Prognostic significance of proliferating cell nuclear antigen expression in colorectal cancer Cancer. ,vol. 71, pp. 1954- 1959 ,(1993) , 10.1002/1097-0142(19930315)71:6<1954::AID-CNCR2820710605>3.0.CO;2-#