Strong expression of cyclin B2 mRNA correlates with a poor prognosis in patients with non-small cell lung cancer
作者： Shinogu Takashima , Hajime Saito , Naoko Takahashi , Kazuhiro Imai , Satoshi Kudo
DOI: 10.1007/S13277-013-1556-7
关键词:
摘要: Cyclin family proteins act in association with cyclin-dependent kinases (CDK) at cell cycle checkpoints to regulate the eukaryotic cycle. CyclinB2 contributes G2/M transition by activating CDK1 kinase, and cyclin B2 inhibition induces arrest. is overexpressed various human tumors, though relationship between expression clinicopathological characteristics of lung cancer patient prognosis not well understood. In present study, therefore, we investigated mRNA patients non-small (NSCLC). We used semiquantitative real-time reverse transcription polymerase chain reaction assess tumor samples from 79 NSCLC. then correlated levels factors. also immunohistochemical staining determine localization expressed B2. The 5-year overall survival rates among adenocarcinoma expressing lower were significantly better than corresponding higher (p = 0.004). Multivariate Cox proportional hazard analyses revealed that gender ((hazard ratio (HR), 9.81; p = 0.044)), n2 (HR, 146.26; p ≤ 0.001), high 7.21; p = 0.021) independent factors affecting rates. However, there was no significance squamous carcinoma level mRNA. Stronger cells an predictor a poor lung.
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