Mast cells augment lesion size and persistence during experimental Leishmania major infection in the mouse.

摘要: Mast cells are a source of variety cytokines that may influence the host response to Leishmania major. To investigate role mast during L. major infection, we performed morphometric analysis at cutaneous sites in resistant C57BL/6 mice and susceptible BALB/c injected with Extensive dermal cell degranulation was found infection both strains mice. We also examined course genetically cell-deficient WBB6F1-W/Wv or WCB6F1-Sl/Sld mice, their respective congenic normal (WBB6F1-(+/+) WCB6F1-(+/+)) littermates, had been selectively locally repaired deficiency. significantly augmented intensity maximal size lesions some cases substantially prolonged persistence reactions. However, ultimately resolved In addition, presence absence little no effect on numbers viable parasites recovered from lesions. Moreover, W/Wv (+/+) produced similar levels IFN-gamma mRNA lymph nodes draining whereas IL-4 detectable. Taken together, these data suggest augment do not appear either parasite burden ultimate resolution infection.