Role of Type 2 T Helper Cells (TH2) in Allergic Disorders

摘要: In the last few years evidence has been provided to suggest existence of functionally distinct subsets CD4+ Th cells in both mice and humans (1,2). At least two polarized forms specific cell-mediated response, based on their mutually exclusive pattern cytokine secretion, have described. Thl, but not Th2 produce IFN-γ TNF-γ, whereas Th2, IL-4 IL-5. Production other cytokines, such as IL-2, IL-10, IL-13 is less restricted than mice, although IL-2 mainly released by Thl cells, IL-10 are cells. Different patterns imply effector functions. which trigger immunity production opsonizing antibodies mediate phagocyte-dependent defence response intracellular infectious agents (3). contrast, responsible for IgE IgG4 antibody production, promote differentiation activation mast eosinophils, they inhibit several macrophage functions, thus being primarily involved phagocyte-independent against extra-cellular parasites addition that fit into Thl- or Th2-polarized phenotypes, identified (Th0 cells), show a composite profile including Th2-type cytokines effects depend ratio produced More recently, human T-cell clones producing were found differ from those even consistent expression CD30 (4), member TNF-R superfamily (5), well release its soluble form (sCD30) (4,6).