Production and Metabolism of Triglyceride-Rich Lipoproteins in Both the Normal and Diabetic States

作者: Angela Pirillo , Giuseppe D. Norata , Alberico L. Catapano

DOI: 10.1007/978-1-4614-7554-5_6

关键词:

摘要: Low-density lipoproteins (LDL), very low-density (VLDL), and chylomicrons are referred to as apolipoprotein B (apoB)-containing exhibit pro-atherogenic characteristics. VLDL, which transport endogenous lipids, produced by the liver, while chylomicrons, diet-derived intestine. After lipoprotein secretion, triglycerides hydrolyzed lipase, fatty acids taken up cells provide energy (in muscle) or be stored adipose tissue). The resulting remnant become enriched in cholesterol can cells.

参考文章(136)
Verne N. Schumaker, Martin L. Phillips, Jon E. Chatterton, Apolipoprotein B and Low-Density Lipoprotein Structure: Implications for Biosynthesis of Triglyceride-Rich Lipoproteins Advances in Protein Chemistry. ,vol. 45, pp. 205- 248 ,(1994) , 10.1016/S0065-3233(08)60641-5
K J Williams, R W Brocia, E A Fisher, The unstirred water layer as a site of control of apolipoprotein B secretion. Journal of Biological Chemistry. ,vol. 265, pp. 16741- 16744 ,(1990) , 10.1016/S0021-9258(17)44822-8
J D Sparks, C E Sparks, Insulin modulation of hepatic synthesis and secretion of apolipoprotein B by rat hepatocytes Journal of Biological Chemistry. ,vol. 265, pp. 8854- 8862 ,(1990) , 10.1016/S0021-9258(19)38966-5
A D Cooper, Hepatic uptake of chylomicron remnants. Journal of Lipid Research. ,vol. 38, pp. 2173- 2192 ,(1997) , 10.1016/S0022-2275(20)34932-4
Robert H Eckel, KGMM Alberti, Scott M Grundy, Paul Z Zimmet, The metabolic syndrome The Lancet. ,vol. 365, pp. 1415- 1428 ,(2005) , 10.1016/S0140-6736(09)61794-3