Abnormal clearance of postprandial Sf 100-400 plasma lipoproteins in insulin-dependent diabetes mellitus.

摘要: Studies were carried out in three normolipidemic non-obese men with insulin-dependent diabetes mellitus (IDDM) and normal men, to assess whether the clearance of postprandial Sf 100-400 lipoproteins is decreased IDDM. greater than 100 isolated from plasma 4.5 h after fat ingestion labeled 125I injected into same subject intravenously. ApoB radioactivity was measured over time 400, 100-400, 20-100 analyzed using a kinetic model that included both fast slow delipidation cascades, where lipolysis uptake particles by liver other tissues represented. Fractional catabolic rates (min-1) diabetic versus control subjects: = 0.170 +/- 0.126 0.680 0.242 (mean SD) (P less 0.05, two-tailed) 0.011 0.006 0.031 0.015 one-tailed). Kinetic analysis showed data consistent for cascade (diabetic, 0.084 0.082, vs. control, 0.617 0.328, P A similar trend observed cascade. There no significant differences between two groups intraplasma particles. Analysis composition they total cholesterol (TC)- triglyceride (TG)-enriched 0.001, log-ratio composition) IDDM subjects.(ABSTRACT TRUNCATED AT 250 WORDS)