Investigating the ability of multiparametric MRI to exclude significant prostate cancer prior to transperineal biopsy

摘要: Introduction: We characterized false negative prostate magnetic resonance imaging (MRI) reporting by using histology derived from MRI-transrectal ultrasound (TRUS)-guided transperineal (MTTP) fusion biopsies. Methods: In total, 148 consecutive patients were retrospectively reviewed. Men underwent multiparametric MRI (mpMRI), reported a consultant/attending radiologist in line with European Society of Urogenital Radiology (ESUR) standards. MTTP biopsy the lesions was performed according to Ginsburg recommendations. Cases an MRI-histology mismatch identified and second read experienced radiologist. A third review direct comparison determine true miss MRI-occult cancer. Statistical analysis McNemar’s test. Results: False 29 examinations (19.6%), total 46 lesions. Most (21/46) located anterior sectors prostate. The led significant decrease false-negative 7/29 further studies as positive on patientby- patient basis (24.1% studies, p = 0.016) 11/46 (23.9%; 0.001). Of these, 30 following first 23 after considered cancer University College London criteria. However, histology, most occult. Conclusion: demonstrate that can fail detect clinically relevant Improved results achieved but despite this, number remain MRI-occult. Further advances are required reduce results.