Bronchodilatation and the site of airway resistance in severe chronic bronchitis.

摘要: Twenty-one patients with severe chronic bronchitis and emphysema (FEV1 less than 1 1) inhaled 80 microgram of the atropine-like agent ipratropium or placebo in a double-blind study three hours later 200 salbutamol. After ipratropium, mean FEV1 was significantly greater after salbutamol (P 0.025), but difference only 40 ml clinical significance this is unproved. There no correlation between patient's response to When administered rose higher levels either alone 0.01). Studies breathing 80% helium/20% oxygen suggest that dilates both large small airways. helium/oxygen bronchodilator. The results at least as effective salbutamol, such should have reversibility studies alone, agents together. combination may be clinically useful.