Effects of Antrodia camphorata on alcohol clearance and antifibrosis in livers of rats continuously fed alcohol.
作者： Min-Tze Wu , Bor-Show Tzang , Yuan-Yen Chang , Chih-Hsien Chiu , Wen-Yu Kang
DOI: 10.1021/JF104561H
关键词:
摘要: Alcoholic fatty liver disease (AFLD) is the result of an excessive or chronic consumption alcohol. Nine male Wistar rats per group were randomly assigned to one following drinking treatments: a 20% (w/w) alcohol solution (ALC); cotreated with 0.25 g silymarin/kg BW/day; 0.025 Niuchangchih ( Antrodia camphorata )/kg BW/day for 4 weeks. Rats cotreatments silymarin had smaller (p 0.05) affect ADH and CYP2E1 expressions, which accelerate metabolism in body. Additionally, neither nor > influenced serum/hepatic MMP-2 activities NF-κB, AP1, α-SMA gene but MMP-9 TNF-α, KLF-6, TGF-β1 expressions alcohol-fed down-regulated < by Niuchangchih, also could explain lower damage observed chronically fed
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sci-hub.se 参考文章(24)
Julio C Fernandes, Jean-Pierre Pelletier, Johanne Martel-Pelletier, The role of cytokines in osteoarthritis pathophysiology. Biorheology. ,vol. 39, pp. 237- 246 ,(2002)
Shun-Fa Yang, Jung-Kai Tseng, Yuan-Yen Chang, Yi-Chen Chen, Flaxseed oil attenuates nonalcoholic fatty liver of hyperlipidemic hamsters. Journal of Agricultural and Food Chemistry. ,vol. 57, pp. 5078- 5083 ,(2009) , 10.1021/JF900499V
Yi Chen, Shigenari Hozawa, Sadaaki Sawamura, Shinkichi Sato, Naoto Fukuyama, Chizuko Tsuji, Tetsuya Mine, Yasunori Okada, Ryuzaburo Tanino, Yoichi Ogushi, Hiroe Nakazawa, Deficiency of inducible nitric oxide synthase exacerbates hepatic fibrosis in mice fed high-fat diet Biochemical and Biophysical Research Communications. ,vol. 326, pp. 45- 51 ,(2004) , 10.1016/J.BBRC.2004.10.202
Chia-Hsin Huang, Yuan-Yen Chang, Cheng-Wei Liu, Wen-Yu Kang, Yi-Ling Lin, Hsien-Chang Chang, Yi-Chen Chen, Fruiting Body of Niuchangchih (Antrodia camphorata) Protects Livers against Chronic Alcohol Consumption Damage Journal of Agricultural and Food Chemistry. ,vol. 58, pp. 3859- 3866 ,(2010) , 10.1021/JF100530C
Analisa DiFeo, John A. Martignetti, Goutham Narla, The role of KLF6 and its splice variants in cancer therapy. Drug Resistance Updates. ,vol. 12, pp. 1- 7 ,(2009) , 10.1016/J.DRUP.2008.11.001
L SOBOLOVA, N SKOTTOVA, R VECERA, K URBANEK, Effect of silymarin and its polyphenolic fraction on cholesterol absorption in rats. Pharmacological Research. ,vol. 53, pp. 104- 112 ,(2006) , 10.1016/J.PHRS.2005.09.004
Riitta Julkunen-Tiitto, Phenolic constituents in the leaves of northern willows: methods for the analysis of certain phenolics Journal of Agricultural and Food Chemistry. ,vol. 33, pp. 213- 217 ,(1985) , 10.1021/JF00062A013
Jhy-Wen Wu, Lie-Chwen Lin, Tung-Hu Tsai, Drug-drug interactions of silymarin on the perspective of pharmacokinetics. Journal of Ethnopharmacology. ,vol. 121, pp. 185- 193 ,(2009) , 10.1016/J.JEP.2008.10.036
George Hsiao, Ming-Yi Shen, Kuan-Hung Lin, Ming-Huang Lan, Li-Yu Wu, Duen-Suey Chou, Chien-Huang Lin, Ching-Hua Su, Joen-Rong Sheu, Antioxidative and Hepatoprotective Effects of Antrodia camphorata Extract Journal of Agricultural and Food Chemistry. ,vol. 51, pp. 3302- 3308 ,(2003) , 10.1021/JF021159T
Shun-Fa Yang, Bor-Show Tzang, Kuo-Tai Yang, Yuan-Chao Hsiao, Yuan-Yen Chang, Chi-Ho Chan, Shih-Guei Fu, Yi-Chen Chen, Taurine alleviates dyslipidemia and liver damage induced by a high-fat/cholesterol-dietary habit Food Chemistry. ,vol. 120, pp. 156- 162 ,(2010) , 10.1016/J.FOODCHEM.2009.10.001