Deficiency of inducible nitric oxide synthase exacerbates hepatic fibrosis in mice fed high-fat diet
作者： Yi Chen , Shigenari Hozawa , Sadaaki Sawamura , Shinkichi Sato , Naoto Fukuyama
DOI: 10.1016/J.BBRC.2004.10.202
关键词:
摘要: Abstract The role of inducible nitric oxide synthase (iNOS) in the progression fibrosis during nonalcoholic steatohepatitis remains to be elucidated. This study examined iNOS by comparing knockout (iNOS−/−) and wild-type (iNOS+/+) mice that were fed a high-fat diet. Severe fatty metamorphosis developed liver iNOS+/+ iNOS−/− mice. Fibrotic changes marked Gelatin zymography showed pro MMP-2 MMP-9 protein expressions more highly induced than Active forms clearly present only tissue In situ strong gelatinolytic activities mice, but spotty activity iNOS−/−mice. may attenuate steatohepatitis, part inducing expression augmenting their activity.
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