The HigB/HigA toxin/antitoxin system of Pseudomonas aeruginosa influences the virulence factors pyochelin, pyocyanin, and biofilm formation.

摘要: Toxin/antitoxin (TA) systems are prevalent in most bacterial and archaeal genomes, one of the emerging physiological roles TA is to help regulate pathogenicity. Although have been studied several model organisms, few studies investigated role pseudomonads. Here, we demonstrate that previously uncharacterized proteins HigB (unannotated) HigA (PA4674) Pseudomonas aeruginosa PA14 form a type II system which antitoxin masks RNase activity toxin through direct binding. Furthermore, reduces production virulence factors pyochelin, pyocyanin, swarming, biofilm formation; hence, this affects pathogencity strain manner has not demonstrated for systems.