Opioid Modulation of Fos Protein Expression and Olfactory Circuitry Plays a Pivotal Role in What Neonates Remember.

摘要: Paradoxically, fear conditioning (odor-0.5 mA shock) yields a learned odor preference in the neonate, presumably due to unique learning and memory circuit that does not include apparent amygdala participation. Post-training opioid antagonism with naltrexone (NTX) blocks consolidation of this instead aversion. Here we characterize neural circuitry underlying switch during consolidation. Experiment 1 assessed post-training modulation Fos protein expression within olfactory (olfactory bulb, piriform cortex, amygdala). Odor-shock no treatment (odor preference) induced significant changes granule cell layer bulb anterior cortex. receptor aversion) prevented learning-induced cortex also central nucleus amygdala. 2 intra-amygdala neonate infusion NTX permitted an aversion, while vehicle-infused pups continued demonstrate preference. Overall, results opioids modulate via modulating circuitry. Furthermore, these suggest are instrumental suppressing behavior