Enduring Effects of Infant Memories: Infant Odor-Shock Conditioning Attenuates Amygdala Activity and Adult Fear Conditioning
作者： Yannick Sevelinges , Stephanie Moriceau , Parker Holman , Cathrine Miner , Kyle Muzny
DOI: 10.1016/J.BIOPSYCH.2007.04.025
关键词: Audiology 、 Classical conditioning 、 Context (language use) 、 Olfactory bulb 、 Psychology 、 Olfaction 、 Developmental psychology 、 Amygdala 、 Odor 、 Conditioning 、 Fear conditioning 、 Biological psychiatry
摘要: Background Early life adverse experience alters adult emotional and cognitive development. Here we assess early learning about its consequences on fear conditioning amygdala activity. Methods Neonatal rats were conditioned daily from 8-12 days-old with paired odor (conditioned stimulus, CS) .5mA shock, unpaired, odor-only, or naive (no infant conditioning). In adulthood, each training group was divided into three groups: paired, unpaired using either the same CS odor, a novel without present as context. Adults cue tested for freezing (odor in environment), 14 C 2-DG autoradiography electrophysiology assessment. Results Infant odor-shock attenuated conditioning, but only if used. The activity correlated produced heightened olfactory bulb Electrophysiological assessment further suggests causes changes processing revealed by increased paired-pulse facilitation adulthood. Conclusions This some enduring effects of adversity (shock) are under control dependent upon their impact later learning.
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Tania L. Roth, Regina M. Sullivan, Memory of early maltreatment: neonatal behavioral and neural correlates of maternal maltreatment within the context of classical conditioning. Biological Psychiatry. ,vol. 57, pp. 823- 831 ,(2005) , 10.1016/J.BIOPSYCH.2005.01.032
A. C. Tang, K. G. Akers, B. C. Reeb, R. D. Romeo, B. S. McEwen, Programming social, cognitive, and neuroendocrine development by early exposure to novelty. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 103, pp. 15716- 15721 ,(2006) , 10.1073/PNAS.0607374103
S. Levine, Plasma-Free Corticosteroid Response to Electric Shock in Rats Stimulated in Infancy Science. ,vol. 135, pp. 795- 796 ,(1962) , 10.1126/SCIENCE.135.3506.795-A
Donald J. Stehouwer, Byron A. Campbell, Habituation of the forelimb-withdrawal response in neonatal rats. Journal of Experimental Psychology: Animal Behavior Processes. ,vol. 4, pp. 104- 119 ,(1978) , 10.1037//0097-7403.4.2.104
A.-M. Mouly, G. Di Scala, Entorhinal cortex stimulation modulates amygdala and piriform cortex responses to olfactory bulb inputs in the rat. Neuroscience. ,vol. 137, pp. 1131- 1141 ,(2006) , 10.1016/J.NEUROSCIENCE.2005.10.024
D Funk, S Amir, Enhanced Fos expression within the primary olfactory and limbic pathways induced by an aversive conditioned odor stimulus Neuroscience. ,vol. 98, pp. 403- 406 ,(2000) , 10.1016/S0306-4522(00)00217-7
Therese A. Kosten, Hongjoo J. Lee, Jeansok J. Kim, Early life stress impairs fear conditioning in adult male and female rats. Brain Research. ,vol. 1087, pp. 142- 150 ,(2006) , 10.1016/J.BRAINRES.2006.03.009
David A Gutman, Charles B. Nemeroff, Neurobiology of early life stress: rodent studies. Seminars in Clinical Neuropsychiatry. ,vol. 7, pp. 89- 95 ,(2002) , 10.1053/SCNP.2002.31781
Robert A. Rescorla, Pavlovian Conditioning and Its Proper Control Procedures Psychological Review. ,vol. 74, pp. 71- 80 ,(1967) , 10.1037/H0024109
Peter C Holland, Michela Gallagher, Amygdala-frontal interactions and reward expectancy. Current Opinion in Neurobiology. ,vol. 14, pp. 148- 155 ,(2004) , 10.1016/J.CONB.2004.03.007