Tip of another iceberg: Drosophila serpins

摘要: Serpins are serine protease inhibitors with a conserved structure that have been identified in nearly all species and act as suicide substrates by binding covalently to their target proteases. regulate various physiological processes defence mechanisms. In humans, several serpin mutations linked diseases. The genome of Drosophila melanogaster encodes 29 serpins even more To date, three investigated detail. Spn27A controls the Toll pathway during early development is involved reactions adult flies. SPN42DaA an inhibitor furin, subtilisin-like convertase required for pro-protein maturation. Spn43Ac immune response. each case, genetics has shed new light on function these inhibitors.