Short-active photoperiod gestation induces psychiatry-relevant behavior in healthy mice but a resiliency to such effects are seen in mice with reduced dopamine transporter expression.

摘要: A higher incidence of multiple psychiatric disorders occurs in people born late winter/early spring. Reduced light exposure/activity level impacts adult rodent behavior and neural mechanisms, yet few studies have investigated such exposure on gestating fetuses. dysfunctional dopamine system is implicated most disorders, genetic polymorphisms reducing expression the transporter (DAT) are associated with some conditions. Furthermore, mice reduced DAT (DAT-HT) were hypersensitive to short active (SA; 19:5 L:D) photoperiod versus their wildtype (WT) littermates. Effects SA during gestation these not been examined. We confirmed females exhibit a heightened corticosterone response when photoperiod. then tested DAT-HT WT littermates psychiatry-relevant behavioral tests after or normal (NA; 12:12 L:D) early life. SA-born exhibited sensorimotor gating deficits (males), increased reward preference, less immobility, open arm avoidance (females), motivation obtain reward, reversal learning deficits, vs. NA-born mice. largely resilient effects, however. Future will determine mechanism(s) by which influences brain development predispose toward emergence behaviors.