Schizophrenia as a Complex Trait

摘要: Context There are many published twin studies of schizophrenia. Although these have been reviewed previously, to our knowledge, no review has provided quantitative summary estimates the impact genes and environment on liability schizophrenia that also accounted for different ascertainment strategies used. Objective To calculate meta-analytic heritability in shared individual-specific environmental effects from pooled data. Data Sources We used a structured literature search identify all schizophrenia, including MEDLINE, dissertation, books-in-print searches. Study Selection Of 14 identified studies, 12 met minimal inclusion criteria systematic ascertainment. Synthesis By using multigroup model, we found evidence substantial additive genetic effects—the point estimate was 81% (95% confidence interval, 73%-90%). Notably, there consistent across common or influences schizophrenia—joint estimate, 11% 3%-19%). Conclusions Despite heterogeneity results with view as complex trait etiological influences. These broadly informative they provide information about specific identity influences, but do component unifying empirical basis supporting rationality searches underlying factors.