Whole-Genome Sequencing of Retinoblastoma Reveals the Diversity of Rearrangements Disrupting RB1 and Uncovers a Treatment-Related Mutational Signature.
作者： Serena Nik-Zainal , Irene Scheimberg , Mandeep S Sagoo , Mandeep S Sagoo , Xueqing Zou
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摘要: … pathological genetic changes in both alleles of the RB1 gene… derived from an ancestral clone that survived six exposures to … for gene mutations that facilitate survival of that clone, during …
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