Sensitization of Nude Mice Using Direct Liposome Transfer of Tumor Cell Antigens

摘要: Transplantable human squamous cell carcinoma cells were coincubated with 1,2-dimyristoylamido-1,2-deoxyphosphatidyl-choline (D14DPC) liposomes. These proteoliposomes and disrupted tumor suspensions injected subcutaneously into two groups of nude mice, respectively, while the third group was untreated. Ten days previously, had been implanted both mice forefeet. In seven-week old pretreated proteoliposomes, one tumors disappeared, another remained unchanged in size remaining regrew. Regrowth observed control groups. Their weight significantly larger (p < 0.05) than those proteoliposome group. all 5-week masses grew but treated smaller other The results showed effectiveness treatment as a possible clinical ap...