Age-Related Decrease in the Inducibility of Heat-Shock Protein 70 in Human Peripheral Blood Mononuclear Cells
作者： R. Njemini , M. Vanden Abeele , C. Demanet , M. Lambert , S. Vandebosch
关键词:
摘要: We have investigated the effect of age and presence proinflammatory cytokines on Hsp 70 production in human peripheral blood mononuclear cells, using flow cytometry. Twenty-seven women 23 men, all apparently healthy, participated study. At 37°C, percentage 70-producing monocytes lymphocytes, as well level monocytes, were negatively influenced by age. After exposure cells to 42°C, increase was more pronounced than lymphocytes; both intensity subjects, for lymphocytes. There a negative correlation between exposed 42°C serum levels tumor necrosis factor-α interleukin-6. In conclusion, heat-induced is reduced with increasing cytokines.
springer.com
sci-hub.se 参考文章(85)
P.K. Sorger, H.R. Pelham, Cloning and expression of a gene encoding hsc73, the major hsp70-like protein in unstressed rat cells. The EMBO Journal. ,vol. 6, pp. 993- 998 ,(1987) , 10.1002/J.1460-2075.1987.TB04850.X
A Y C Liu, Z Lin, H S Choi, F Sorhage, B Li, Attenuated induction of heat shock gene expression in aging diploid fibroblasts. Journal of Biological Chemistry. ,vol. 264, pp. 12037- 12045 ,(1989) , 10.1016/S0021-9258(18)80171-5
Richard I. Morimoto, Costa Georgopoulos, Alfred Tissières, 1 Progress and Perspectives on the Biology of Heat Shock Proteins and Molecular Chaperones Cold Spring Harbor Monograph Archive. ,vol. 26, pp. 1- 30 ,(1994) , 10.1101/087969427.26.1
Csaba Sőti, Péter Csermely, Molecular chaperones and the aging process. Biogerontology. ,vol. 1, pp. 225- 233 ,(2000) , 10.1023/A:1010082129022
S A Sporn, G Martin, S Haskill, C E Johnson, M Ladner, D F Eierman, J Morris, Monocyte adherence results in selective induction of novel genes sharing homology with mediators of inflammation and tissue repair. Journal of Immunology. ,vol. 144, pp. 4434- 4441 ,(1990)
Catherine M. Cahill, Wayne R. Waterman, Yue Xie, Philip E. Auron, Stuart K. Calderwood, Transcriptional Repression of the Prointerleukin 1β Gene by Heat Shock Factor 1 Journal of Biological Chemistry. ,vol. 271, pp. 24874- 24879 ,(1996) , 10.1016/S0021-9258(18)40087-7
M Jäättelä, None, Overexpression of major heat shock protein hsp70 inhibits tumor necrosis factor-induced activation of phospholipase A2. Journal of Immunology. ,vol. 151, pp. 4286- 4294 ,(1993)
Stephen P. Tomasovic, Jim Klostergaard, Marketa Barta, Hyperthermic Modulation of Respiratory Inhibition Factor- and Iron Releasing Factor-dependent Macrophage Murine Tumor Cytotoxicity Cancer Research. ,vol. 49, pp. 6252- 6257 ,(1989)
H S Choi, Z Lin, B S Li, A Y Liu, Age-dependent decrease in the heat-inducible DNA sequence-specific binding activity in human diploid fibroblasts. Journal of Biological Chemistry. ,vol. 265, pp. 18005- 18011 ,(1990) , 10.1016/S0021-9258(18)38263-2
B Wu, C Hunt, R Morimoto, Structure and expression of the human gene encoding major heat shock protein HSP70. Molecular and Cellular Biology. ,vol. 5, pp. 330- 341 ,(1985) , 10.1128/MCB.5.2.330