Novel one-pot total syntheses of deoxyvasicinone, mackinazolinone, isaindigotone, and their derivatives promoted by microwave irradiation.
作者： Ji-Feng Liu , Ping Ye , Kevin Sprague , Katie Sargent , Daniel Yohannes
DOI: 10.1021/OL0513084
关键词:
摘要: [reaction: see text]. Total syntheses of deoxyvasicinone (1), mackinazolinone (2), and 8-hydroxydeoxyvasicinone (3) via novel microwave-assisted domino reactions, as well a three-component one-pot total synthesis isaindigotone (5) promoted by microwave irradiation, are reported. The efficient reaction process enabled us to rapidly access related natural product derivatives identify new class cytotoxic agents.
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