Synthesis and cytotoxic evaluation of some new 4(3H)-quinazolinones on HeLa cell line.
作者： M Shamshiri , F Hassanzadeh , G A Khodarahmi
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摘要: Quinazolinone backbone is present in a large number of bioactive substances. Since remarkable cytotoxic activity associated with some 4(3H)-quinazolinones, this study 4(3H)-quinazolinone were synthesized and screened against HeLa cells. The synthesis was performed via reaction anthranilic acid dicarboxylic anhydrides to produce carboxylic acids derivatives. products heated acetic anhydride benzoxazinones. Finally, 4(3H)-quinazolinones by between benzoxazinones primary amines. assessment the structure compounds based on spectral data (FT-IR, Mass 1 HNMR). Subsequently, 3, 6, 9 13 (individually combination doxorubicin) evaluated cell line using MTT assay. results indicated that tested did not show significant cytotoxicity alone doxorubicin (1 20 µM).
参考文章(13)
Ji-Feng Liu, Ping Ye, Kevin Sprague, Katie Sargent, Daniel Yohannes, Carmen M. Baldino, Christopher J. Wilson, Shi-Chung Ng, Novel one-pot total syntheses of deoxyvasicinone, mackinazolinone, isaindigotone, and their derivatives promoted by microwave irradiation. Organic Letters. ,vol. 7, pp. 3363- 3366 ,(2005) , 10.1021/OL0513084
S. Jantová, L’. C̆ipák, D. Slamen̆ová, V. Horváth, P. Rauko, Induction of cytotoxicity and ssDNA breaks by 9-bromo-5-morpholino-tetrazolo[1,5-c]quinazoline in tumor cells cultured in vitro. Toxicology in Vitro. ,vol. 17, pp. 457- 463 ,(2003) , 10.1016/S0887-2333(03)00066-3
Ahmed Kamal, E. Vijaya Bharathi, M. Janaki Ramaiah, D. Dastagiri, J. Surendranadha Reddy, A. Viswanath, Farheen Sultana, S.N.C.V.L. Pushpavalli, Manika Pal-Bhadra, Hemant Kumar Srivastava, G. Narahari Sastry, Aarti Juvekar, Subrata Sen, Surekha Zingde, Quinazolinone linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates: Design, synthesis and biological evaluation as potential anticancer agents. Bioorganic & Medicinal Chemistry. ,vol. 18, pp. 526- 542 ,(2010) , 10.1016/J.BMC.2009.12.015
Periyasamy Selvam, Padamraj Rathore, P. Babu, Leentje Persoons, Erik de Clercq, Synthesis, Antiviral and Cytotoxic Activities of SomeNovel 2,3-Disubstituted Quinazolin-4(3H)-Ones Antiviral Research. ,vol. 78, ,(2008) , 10.1016/J.ANTIVIRAL.2008.01.138
Ji-Feng Liu, Christopher J. Wilson, Ping Ye, Kevin Sprague, Katie Sargent, Ying Si, Galina Beletsky, Daniel Yohannes, Shi-Chung Ng, Privileged structure-based quinazolinone natural product-templated libraries: Identification of novel tubulin polymerization inhibitors Bioorganic & Medicinal Chemistry Letters. ,vol. 16, pp. 686- 690 ,(2006) , 10.1016/J.BMCL.2005.10.022
H.M.F. Madkour, Reactivity of 4H-3,1-benzoxazin-4-ones towards nitrogen and carbon nucleophilic reagents: applications to the synthesis of new heterocycles Arkivoc. ,vol. 2004, ,(2004) , 10.3998/ARK.5550190.0005.103
M. Iqbal Choudhary, Shazia Anjum, Abdul Majeed Khan, Synthesis of Bioactive Succinylanthranilic Acid Ester and its Analogues ,(2006)
M. Bouachrine, F. Lamchouri, M. Hamidi, H. Toufik, Experimental and computational study of biological activities of alkaloids isolated from Peganum harmala seeds ,(2010)
Atul Bendale, Akhil A. Nagar, Vilas J. Pise, Naresh Chugh, L. G. Rathi, Microwave Assisted One Pot Synthesis of 2, 3-Di-Substituted Quinazolin-4-(3h)-Ones and Their Potential Biological Activity Der Pharma Chemica. ,vol. 2, pp. 37- 43 ,(2010)
Warren Ae, Hall Ih, Barnes Cr, Izydore Ra, Cytotoxicity and mode of action of aliphatic dicarboxylic acids in L1210 lymphocytic leukemia cells. Anticancer Research. ,vol. 19, pp. 205- 211 ,(1999)