A "patient-tailored" treatment of hypertension with use of impedance cardiography: a randomized, prospective and controlled trial.

摘要: BACKGROUND: Arterial hypertension might be caused by hemodynamic disturbances such as fluid retention, increased vascular resistance, and hyperdynamic function of the heart. The aim this study was to estimate effectiveness antihypertensive therapy based on assessment impedance cardiography in a randomized, prospective, controlled trial. MATERIAL AND METHODS: This involved 128 patients (average age: 42.9 ± 11.1 years) with arterial hypertension, randomized into groups: (1) empiric, (2) hemodynamic, which treatment choice considered results. Evaluation effects performed after 12 weeks included office blood pressure measurement ambulatory monitoring. RESULTS: All final values were lower group, significantly for systolic (empiric vs. hemodynamic: 136.1 131.6 mmHg; p=0.036) diastolic (87.0 83.7 p=0.013), well night-time (121.3 117.2 p=0.023) (71.9 68.4 p=0.007). Therapy reduction (11.0 17.3 p=0.008) (7.7 12.2 p=0.0008); 24-h mean (9.8 14.2 p=0.026), daytime (10.5 14.8 p=0.040), p=0.032). CONCLUSIONS: Antihypertensive can increase hypertensive patients.