Protein Kinase C Isoforms Distinctly Regulate Propofol-induced Endothelium-dependent and Endothelium-independent Vasodilation

作者: Yan Wang , Huixuan Zhou , Bin Wu , Quanhong Zhou , Derong Cui

DOI: 10.1097/FJC.0000000000000275

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摘要: Abstract:Protein kinase C (PKC) isoforms improve endothelial nitric oxide synthase activity and contractile Ca2+ sensitivity in blood vessels. These actions may have opposite effects on propofol-induced vasodilation. This study examines the hypothesis that propofol induces relaxation by enhancing th

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