[Calcitonin as an analgesic agent: review of mechanisms of action and clinical applications].

摘要: Abstract Background and objectives Calcitonin is a polypeptide hormone regulating the metabolism of calcium in body. For many years calcitonin has been used to maintain improve bone mineral density reduce fracture rate. Many studies showed that had analgesic role several painful circumstances. This pain-ameliorating effect irrelevant its osteoclastic inhibitory mechanisms like altering Na+ channel serotonin receptor expression or hypothesis including endorphin-mediated mechanism were explain this effect. In study we performed thorough review on as an agent different scenarios investigated fact can be feasible medication relieve pain. Method focused circumstances, acute pains related vertebral fractures, metastasis, migraine reflex sympathetic dystrophy well neuropathic spinal injuries diabetes, phantom Also, was useful additive local anesthesia case controlling postoperative pain trigeminal neuralgia more effectively. However faced some contradictory data for conditions lumbar canal stenosis, complex regional syndrome, malignancies. Conclusion could helpful situations. considered eligible treatment fractures alternative chronic where other medications might fail.