作者: Susan Irene Hershenson , John David Young , Thomas Charles Boone , Ellen Ngoi Yin Cheung
DOI:
关键词:
摘要: The in vivo circulating life and/or absorption of cationic therapeutic proteins, including but not limited to basic proteins such as NT-3, can be increased by generating analogs that have a lower isoelectric point and, preferably, also protein charge relative the native sequence.