Advances in molecular carcinogenesis: current and future use of mouse models to screen and validate molecularly targeted anticancer drugs.

摘要: Survival of patients with advanced solid tumors has not significantly improved over the past 30 years. Although molecularly targeted anticancer drugs offer promise, few make it through end Food and Drug Administration approval process. Animal models that more closely resemble human carcinogenesis may bridge gap between preclinical success benefits for patients. We discuss pros cons several mouse models, including genetically engineered mice each represent different aspects cancer, screening in these models. Published 2004 Wiley-Liss, Inc.