Role of the Na+/K+-ATPase ion pump in male reproduction and embryo development.
作者： D. R. Câmara , J. P. Kastelic , J. C. Thundathil
DOI: 10.1071/RD16091
关键词:
摘要: Na+/K+-ATPase was one of the first ion pumps studied because its importance in maintaining osmotic and ionic balances between intracellular extracellular environments, through exchange three Na+ ions out two K+ into a cell. This enzyme, which comprises main subunits (α β), with or without an auxiliary polypeptide (γ), can have specific biochemical properties depending on expression associated isoforms (α1β1 and/or α2β1) In addition to ensuring function many tissues (e.g. brain, heart kidney), reproductive tract this protein is essential for embryo development roles blastocoel formation hatching. context male reproduction, discovery very subunit (α4), apparently restricted germ cells, only expressed after puberty able influence sperm motility capacitation), opened remarkable field further investigations regarding biology. Therefore, present review focuses reproduction development.
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