Fornix Stimulation Induces Metabolic Activity and Dopaminergic Response in the Nucleus Accumbens

作者: Hojin Shin , Sang-Yoon Lee , Hyun-U Cho , Yoonbae Oh , In Young Kim

DOI: 10.3389/FNINS.2019.01109

关键词:

摘要: The Papez circuit, including the fornix white matter bundle, is a well-known neural network that involved in multiple limbic functions such as memory and emotional expression. We previously reported large-animal study of deep brain stimulation (DBS) found stimulation-induced hemodynamic responses both medial corticolimbic circuits on functional resonance imaging (fMRI) evoked dopamine nucleus accumbens (NAc), measured by fast-scan cyclic voltammetry (FSCV). effects DBS are challenging to analyze, given its structural complexity connection neuronal networks. In this study, we extend our earlier work rodent model wherein characterize regional activity changes resulting from using fludeoxyglucose (18F-FDG) micro positron emission tomography (PET) monitor neurochemical FSCV with pharmacological confirmation. Both global local were DBS. Functional was micro-PET, areas monitored FSCV. Micro-PET images revealed increased glucose metabolism within circuits. Neurotransmitter efflux induced at NAc identified specific neurotransmitter reuptake inhibitors. significant increase metabolic several key regions following stimulation. These results suggest electrical modulates circuits, hippocampus dopaminergic pathway.

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