Mapping the gene for hereditary cutaneous malignant melanoma-dysplastic nevus to chromosome 1p

摘要: Abstract We used molecular genetic techniques and multipoint linkage analyses to locate the gene responsible for cutaneous malignant melanoma-dysplastic nevus. evaluated 99 relatives 26 spouses in six families with a predisposition melanoma. Thirty-four family members had melanoma, 31 of these 34 also histologically confirmed dysplastic nevi. Twenty-four nevi alone. An analysis cosegregation melanoma–dysplastic nevus trait polymorphic DNA markers on short arm chromosome 1 demonstrated presence susceptibility The was located between an anonymous marker (D1S47) locus pronatrodilatin, commonly reference (PND), band 1p36. odds were greater than 260,000:1 favor at this location. (N Engl J Med 1989;320:1367–72.)