Karyotypic evolution in human malignant melanoma.

摘要: Chromosome studies were performed on direct preparations, early passage cultures, and cell lines derived from melanocytic lesions of 37 patients. There six congenital or common acquired nevi, dysplastic one primary melanoma (radial growth phase), three complex melanomas (RGP with foci vertical advanced (VGP), 26 metastases. The karyotype was normal in the nevi. A chromosomally abnormal clone a single karyotypic alteration found two All had clones multiple cytogenetic changes. Nonrandom abnormalities involving translocations deletions short arm chromosome #1, either #6, and/or extra copies #7 present all melanomas. These not obviously associated particular stage disease, except that only nonrandom (RGP) involved #6. In four cases, data available both its each instance there alterations (demonstrating clonality disease), as well additional changes Our findings indicate demonstrable somatic genetic increase severity clinical progression but are required to establish significance specific (and genes) evolution these disorders.