Cystic fibrosis of the pancreas: involvement of MUC6 mucin in obstruction of pancreatic ducts.

摘要: Cystic fibrosis (CF) is characterized by pancreatic destruction following the gradual obstruction of small ducts, from mid-trimester gestation onwards. To date, material causing has not been identified. The MUC6 mucin cDNA was isolated human stomach and shown to be expressed in a number other tissues gastrointestinal tract, including gall bladder parts ileum colon. We have examined expression pancreas, both during development postnatally, mRNA situ hybridization immunocytochemistry. In this report we establish that transcripts are abundant epithelial cells show very similar pattern epithelium lining ducts centroacinar cystic transmembrane conductance regulator gene (CFTR). addition, obstructing CF pancreas contain mucin. identified as significant constituent CF.