Determination of risk for Barrett's esophagus and esophageal adenocarcinoma.

摘要: Purpose of review The incidence esophageal adenocarcinoma and its precursor, Barrett's esophagus, have increased greatly over the past 40 years continue to rise. This report summarizes most recent data on risk factors for esophagus adenocarcinoma. Recent findings Other factors, highly correlated with increasing trends obesity, are dominant driver increase in adenocarcinoma, interacting gastroesophageal reflux disease symptoms. Abdominal independently symptoms, is associated this association likely mediated by high levels leptin insulin. Use aspirin, nonsteroidal anti-inflammatory drugs, statins, proton pump inhibitors a reduced as well lower neoplastic progression patients esophagus. An number genetic loci been Summary advances identifying reporting more precise estimates effect main will positively impact clinical stratification efforts Large pooling studies underway derive validate reliable models.