Supportive evidence for FOXP1, BARX1, and FOXF1 as genetic risk loci for the development of esophageal adenocarcinoma
作者： Jessica Becker , Andrea May , Christian Gerges , Mario Anders , Lothar Veits
DOI: 10.1002/CAM4.500
关键词:
摘要: The Barrett's and Esophageal Adenocarcinoma Consortium (BEACON) recently performed a genome-wide association study (GWAS) on esophageal adenocarcinoma (EAC) esophagus. They identified significant for variants at three genes, namely CRTC1, FOXP1, BARX1. Furthermore, they replicated an the FOXF1 gene that has been previously found in GWAS We aimed further replicating these other loci showed suggestive with P < 10(-4) BEACON sample. In total, we tested 88 SNPs independent sample consisting of 1065 EAC cases 1019 controls German descent. could replicate BARX1, nominal significance thereby confirm genetic genes confer risk. addition, near XRCC2 GATA6 were strongly (P 10(-5) ) although not significantly associated GWAS. Therefore, both corresponding represent promising candidates future studies samples.
uq.edu.au
mpg.de
core.ac.uk参考文章(11)
Erik T. Kimchi, Mitchell C. Posner, James O. Park, Thomas E. Darga, Masha Kocherginsky, Theodore Karrison, John Hart, Kerrington D. Smith, James J. Mezhir, Ralph R. Weichselbaum, Nikolai N. Khodarev, Progression of Barrett's Metaplasia to Adenocarcinoma Is Associated with the Suppression of the Transcriptional Programs of Epidermal Differentiation Cancer Research. ,vol. 65, pp. 3146- 3154 ,(2005) , 10.1158/0008-5472.CAN-04-2490
Hector Alvarez, Joanna Opalinska, Li Zhou, Davendra Sohal, Melissa J Fazzari, Yiting Yu, Christina Montagna, Elizabeth A Montgomery, Marcia Canto, Kerry B Dunbar, Jean Wang, Juan Carlos Roa, Yongkai Mo, Tushar Bhagat, KH Ramesh, Linda Cannizzaro, J Mollenhauer, Reid F Thompson, Masako Suzuki, Stephen Meltzer, Ari Melnick, John M Greally, Anirban Maitra, Amit Verma, None, Widespread Hypomethylation Occurs Early and Synergizes with Gene Amplification during Esophageal Carcinogenesis PLOS Genetics. ,vol. 7, ,(2011) , 10.1371/JOURNAL.PGEN.1001356
W. Shu, M. M. Lu, Y. Zhang, P. W. Tucker, D. Zhou, E. E. Morrisey, Foxp2 and Foxp1 cooperatively regulate lung and esophagus development. Development. ,vol. 134, pp. 1991- 2000 ,(2007) , 10.1242/DEV.02846
Y Gu, S Lin, J-L Li, H Nakagawa, Z Chen, B Jin, L Tian, D A Ucar, H Shen, J Lu, S N Hochwald, F J Kaye, L Wu, Altered LKB1/CREB-regulated transcription co-activator (CRTC) signaling axis promotes esophageal cancer cell migration and invasion. Oncogene. ,vol. 31, pp. 469- 479 ,(2012) , 10.1038/ONC.2011.247
David M Levine, Weronica E Ek, Rui Zhang, Xinxue Liu, Lynn Onstad, Cassandra Sather, Pierre Lao-Sirieix, Marilie D Gammon, Douglas A Corley, Nicholas J Shaheen, Nigel C Bird, Laura J Hardie, Liam J Murray, Brian J Reid, Wong-Ho Chow, Harvey A Risch, Olof Nyrén, Weimin Ye, Geoffrey Liu, Yvonne Romero, Leslie Bernstein, Anna H Wu, Alan G Casson, Stephen J Chanock, Patricia Harrington, Isabel Caldas, Irene Debiram-Beecham, Carlos Caldas, Nicholas K Hayward, Paul D Pharoah, Rebecca C Fitzgerald, Stuart MacGregor, David C Whiteman, Thomas L Vaughan, None, A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus Nature Genetics. ,vol. 45, pp. 1487- 1493 ,(2013) , 10.1038/NG.2796
L. Lin, A. J. Bass, W. W. Lockwood, Z. Wang, A. L. Silvers, D. G. Thomas, A. C. Chang, J. Lin, M. B. Orringer, W. Li, T. W. Glover, T. J. Giordano, W. L. Lam, M. Meyerson, D. G. Beer, Activation of GATA binding protein 6 (GATA6) sustains oncogenic lineage-survival in esophageal adenocarcinoma Proceedings of the National Academy of Sciences of the United States of America. ,vol. 109, pp. 4251- 4256 ,(2012) , 10.1073/PNAS.1011989109
John Thacker, The RAD51 gene family, genetic instability and cancer Cancer Letters. ,vol. 219, pp. 125- 135 ,(2005) , 10.1016/J.CANLET.2004.08.018
Zhan Su, Laura J Gay, Amy Strange, Claire Palles, Gavin Band, David C Whiteman, Francesco Lescai, Cordelia Langford, Manoj Nanji, Sarah Edkins, Anouk Van Der Winkel, David Levine, Peter Sasieni, Céline Bellenguez, Kimberley Howarth, Colin Freeman, Nigel Trudgill, Art T Tucker, Matti Pirinen, Maikel P Peppelenbosch, Luc JW Van Der Laan, Ernst J Kuipers, Joost PH Drenth, Wilbert H Peters, John V Reynolds, Dermot P Kelleher, Ross McManus, Heike Grabsch, Hans Prenen, Raf Bisschops, Kausila Krishnadath, Peter D Siersema, Jantine WPM Van Baal, Mark Middleton, Russell Petty, Richard Gillies, Nicola Burch, Pradeep Bhandari, Stuart Paterson, Cathryn Edwards, Ian Penman, Kishor Vaidya, Yeng Ang, Iain Murray, Praful Patel, Weimin Ye, Paul Mullins, Anna H Wu, Nigel C Bird, Helen Dallal, Nicholas J Shaheen, Liam J Murray, Konrad Koss, Leslie Bernstein, Yvonne Romero, Laura J Hardie, Rui Zhang, Helen Winter, Douglas A Corley, Simon Panter, Harvey A Risch, Brian J Reid, Ian Sargeant, Marilie D Gammon, Howard Smart, Anjan Dhar, Hugh McMurtry, Haythem Ali, Geoffrey Liu, Alan G Casson, Wong-Ho Chow, Matt Rutter, Ashref Tawil, Danielle Morris, Chuka Nwokolo, Peter Isaacs, Colin Rodgers, Krish Ragunath, Chris MacDonald, Chris Haigh, David Monk, Gareth Davies, Saj Wajed, David Johnston, Michael Gibbons, Sue Cullen, Nicholas Church, Ruth Langley, Michael Griffin, Derek Alderson, Panos Deloukas, Sarah E Hunt, Emma Gray, Serge Dronov, Simon C Potter, Avazeh Tashakkori-Ghanbaria, Mark Anderson, Claire Brooks, Jenefer M Blackwell, Elvira Bramon, Matthew A Brown, Juan P Casas, Aiden Corvin, Audrey Duncanson, Hugh S Markus, Christopher G Mathew, Colin NA Palmer, Robert Plomin, Anna Rautanen, Stephen J Sawcer, Richard C Trembath, Ananth C Viswanathan, Nicholas Wood, Gosia Trynka, Cisca Wijmenga, Jean-Baptiste Cazier, Paul Atherfold, Anna M Nicholson, Nichola L Gellatly, Deborah Glancy, Sheldon C Cooper, David Cunningham, Tore Lind, Julie Hapeshi, David Ferry, Barrie Rathbone, Julia Brown, Sharon Love, Stephen Attwood, Stuart MacGregor, Peter Watson, Scott Sanders, Weronica Ek, Rebecca F Harrison, Paul Moayyedi, John De Caestecker, Hugh Barr, Elia Stupka, Thomas L Vaughan, Leena Peltonen, Chris CA Spencer, Ian Tomlinson, Peter Donnelly, Janusz AZ Jankowski, None, Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus Nature Genetics. ,vol. 44, pp. 1131- 1136 ,(2012) , 10.1038/NG.2408
Janghee Woo, Isabelle Miletich, Byeong-Moo Kim, Paul T. Sharpe, Ramesh A. Shivdasani, Barx1-Mediated Inhibition of Wnt Signaling in the Mouse Thoracic Foregut Controls Tracheo-Esophageal Septation and Epithelial Differentiation PLoS ONE. ,vol. 6, pp. e22493- ,(2011) , 10.1371/JOURNAL.PONE.0022493
Henry B Koon, Gregory C Ippolito, Alison H Banham, Philip W Tucker, FOXP1: a potential therapeutic target in cancer Expert Opinion on Therapeutic Targets. ,vol. 11, pp. 955- 965 ,(2007) , 10.1517/14728222.11.7.955