Genetic polymorphism of human salivary proline-rich proteins: Further genetic analysis

摘要: Electrophoresis of concentrated parotid saliva on slab polyacrylamide gels negatively stained with 3,3′-dimethoxybenzidine and hydrogen peroxide (DMB stain) showed nine phenotypes among the proline-rich proteins. These are expression four autosomal codominant alleles. Gene frequencies are, for Caucasians, Pr1=0.640, Pr1′=0.005, Pr2=0.080, Pr2′=0.275; Negroes, Pr1=0.700, Pr1′=0.050, Pr2′=0.170; Chinese, Pr1=0.770, Pr1′=0, Pr2=0, Pr2′=0.230. The presence or absence another pair proteins giving same negative staining is inherited as an dominant trait (Db). Homozygous Db + heterozygous − individuals could not be distinguished. genetic determinant (Db) this either closely linked to part Pr locus. Db+=0.12, Db−=0.88; Db+=0.56, Db−=0.44; Db+=0.07, Db−=0.93.