Oncogenic Signaling Pathways in The Cancer Genome Atlas

作者: Francisco Sanchez-Vega , Marco Mina , Joshua Armenia , Walid K Chatila , Augustin Luna

DOI: 10.1016/J.CELL.2018.03.035

关键词:

摘要: Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, co-occurrence these differ between individual tumors tumor types. Using mutations, copy-number changes, mRNA expression, gene fusions DNA methylation 9,125 profiled by The Cancer Genome Atlas (TCGA), we analyzed mechanisms patterns somatic ten canonical pathways: cycle, Hippo, Myc, Notch, Nrf2, PI-3-Kinase/Akt, RTK-RAS, TGFβ signaling, p53 β-catenin/Wnt. We charted detailed landscape pathway 33 cancer types, stratified into 64 subtypes, identified mutual exclusivity. Eighty-nine percent had at least one driver alteration pathways, 57% potentially targetable currently available drugs. Thirty multiple alterations, indicating opportunities for combination therapy.

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