Immunogenetics: genetic polymorphism and susceptibility to neurological disease
作者： D.A.S. Compston , R.J. Swingler
DOI: 10.1016/B978-0-407-02400-7.50023-8
关键词:
摘要: Publisher Summary This chapter discusses genetic polymorphism and its role in neurological disease. Immune response involves a sequence which complex antigen is absorbed, processed, presented to T-helper lymphocytes, activate suppressor subpopulations, cytotoxic T cells, B lymphocytes. These processes are regulated by highly polymorphic genes, grouped within the major histocompatibility (MHC)—in man, HLA system—that encode proteins determining recognition events at cell surfaces. The system lies on short arm of chromosome 6 distal portion 6p21.3 band 1–2 cm long. Class 1 class 2 antigens regulate immune function restricting T-cell activation effector responses; 3 products involved classical alternate complement pathways. consist an invariable polypeptide chain encoded 15, inserted into membrane. genetics biology MHC gene products. It also explores etiology multiple sclerosis.
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