Viral infection in patients with multiple sclerosis and HLA-DR matched controls.

摘要: Retrospective comparisons of the prevalence and age, where appropriate, some childhood infectious illnesses vaccinations, together with serological evidence for exposure to 16 viruses, many which have previously been implicated in aetiology multiple sclerosis (MS) were made 177 patients acute optic neuritis, other recent isolated demyelinating episodes or established MS 164 controls. The expected high frequency HLA-DR2 disease was matched by preselection normal controls this antigen (DR2+); remaining individuals classified as negative/DR3 positive (DR3+) 3 negative (DR2/3 -). Cases compared controls, collectively analyses restricted each genetic group; these repeated considering three categories demyelination two control populations separately. All DR2+, DR3+ DR2/3 - a single analysis assess effect HLA type itself on results. Patients had rubella measles at later age reported mumps infection more frequently than Age typhoid vaccination duration domestic dogs higher all cases mumps, but not rubella, DR2+ controls; differences observed groups. Higher antibody titres present confined whom Epstein Barr virus also present. Measles haemagglutination inhibition parainfluenza I increased influenza A antibodies detected less neuritis those DR2 appropriate B lower adenovirus varicella zoster DR2/3- neurological diseases Overall, older often particular cases, Our results are consistent presence abnormal HLA-immunological reactivity cannot be explained only an DR itself; susceptible develop common infections may influence subsequent development disease.