Obesity as a cardiovascular risk factor

摘要: Abstract The prevalence of overweight and obesity continues to increase rapidly in the United States, with more than half all adults currently or obese. In general, people become obese because a combination inherited genes lifestyle consisting low levels physical activity consumption excess calories. Obesity, especially central visceral type, is predisposing factor for development type 2 diabetes mellitus, hypertension, cardiovascular disease (CVD). Obesity are associated insulin resistance. relation among obesity, resistance, CVD appears develop at relatively young age. Central linked hyperinsulinemia, dyslipidemia, proinflammatory prothrombotic clinical states. Adipose tissue synthesizes secretes biologically active molecules that may affect risk factors. These chemical messengers include adiponectin, resistin, leptin, plasminogen activator inhibitor–1, tumor necrosis factor–α, interleukin-6. individuals, weight loss improve sensitivity, leading reduction factors and, consequently, potential events. Agents such as thiazolidinediones, have been shown reduce obesity. Decreases adipose contribute improvements sensitivity blood pressure, reduces serum triglycerides low-density lipoprotein cholesterol while increasing high-density cholesterol. Reduction suggests will be reduced by improvement loss.