The expression profile of genes involved in osteoclastogenesis detected in whole blood of Arabian horses during 3 years of competing at race track.

摘要: One of the most significant reason economic loss on race track performance is lame in performed horses. Primarily, due to failure within proper bone maintenance during conditioning young The training overload causes turnover disturbances homeostasis between resorption and formation which promote loss. Within our study we investigated induced changes transcript abundance genes (NFATc1, CTSK, DAP12, CLEC5A, IL6ST, VAV3) involved osteoclastogenesis hence resorption, whole blood Arabian expression pattern all analysed varied depend exercise intense activity. All stages generate similar response whatever season was. initial had greater effect than increased, prolonged, established conditioning. Notwithstanding, increase was observed period starts with racing competition. There no biomarker known highly accuracy according degree articular cartilage or disease a single joint. Thus, markers presented report, poses potential be further investigate as useful tool for turnover.