Development of a guided bone regeneration device using salicylic acid‐poly(anhydride‐ester) polymers and osteoconductive scaffolds
作者： Ashley Mitchell , Brian Kim , Jessica Cottrell , Sabrina Snyder , Lukasz Witek
DOI: 10.1002/JBM.A.34728
关键词:
摘要: Successful repair of craniofacial and periodontal tissue defects ideally involves a combined therapy that includes inflammation modulation, control soft infiltration, bone regeneration. In this study, an anti-inflammatory polymer, salicylic acid-based poly(anhydride-ester) (SAPAE) three-dimensional osteoconductive ceramic scaffold were evaluated as guided regeneration (GBR) system for concurrent inflammation, ingrowth, in rabbit cranial defect model. At time periods 1, 3, 8 weeks, five groups compared: (1) scaffolds with solid cap (as GBR structure); (2) no cap; (3) poly(lactide-glycolide) (4) slow release SAPAE polymer (5) fast cap. Cellular infiltration formation these to assess capacity the test groups. The polymers suppressed displayed deleterious effect on formation. Additional work is warranted optimize action SAPAE, suppression stimulation create composite device successful defects.
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