Myricetin protects against diet-induced obesity and ameliorates oxidative stress in C57BL/6 mice

摘要: Myricetin is a naturally occurring antioxidant commonly found in various plants. However, little information available with respect to its direct anti-obesity effects. This study was undertaken investigate the effect of myricetin on high-fat diet (HFD)-induced obesity C57BL/6 mice. Administration dramatically reduced body weight diet-induced obese mice compared solely HFD-induced Several parameters related including serum glucose, triglyceride, and cholesterol were significantly decreased myricetin-treated Moreover, obesity-associated oxidative stress (glutathione peroxidase (GPX) activity, total capacity (T-AOC), malondialdehyde (MDA)) inflammation (tumor necrosis factor-α (TNF-α)) ameliorated Further investigation revealed that protective against appeared be partially mediated through down-regulation mRNA expression adipogenic transcription factors peroxisome proliferator-activated receptor γ (PPARγ) CCAAT/enhancer-binding protein α (C/EBPα), lipogenic factor sterol regulatory element-binding 1c (SREBP-1c). Consumption may help prevent obesity-related metabolic complications.