Two-chiral component microemulsion EKC - chiral surfactant and chiral oil. Part 2: diethyl tartrate.

摘要: In this second study on dual-chirality microemulsions containing a chiral surfactant and oil, less hydrophobic lower interfacial tension diethyl tartrate, is employed (Part 1, Foley, J. P. et al.., Electrophoresis, DOI: 10.1002/elps.200600551). Six stereochemical combinations of dodecoxycarbonylvaline (DDCV: R, S, or racemic, 2.00% w/v), racemic 2-hexanol (1.65% v/v), tartrate (D, L, 0.88% v/v) were examined as pseudostationary phases (PSPs) for the enantioseparation six pharmaceutical compounds: pseudoephedrine, ephedrine, N-methyl metoprolol, synephrine, atenolol. Average efficiencies increased with addition oil to R-DDCV PSP formulations. Modest improvements in resolution enantioselectivity (alpha(enant)) achieved two-chiral-component systems over one-chiral-component microemulsion. Slight enantioselective synergies confirmed using thermodynamic model. Results obtained are compared those Part 1 well MEEKC an achiral, low-interfacial-tension (ethyl acetate). Dual-chirality more dibutyl yielded, relative higher (100,000-134,000 vs. 80,800-94,300), but (1.64-1.91 2.08-2.21) due enantioselectivities (1.060-1.067 1.078-1.081). Atenolol enantiomers could not be separated tartrate-based partially resolved microemulsions. A comparable single-chirality microemulsion based achiral ethyl acetate efficiency (78 300 91 600), (1.99 1.83), similar enantioselectivities.