Microarray analysis revealing common and distinct functions of promyelocytic leukemia protein (PML) and tumor necrosis factor alpha (TNFα) signaling in endothelial cells
作者： Xiwen Cheng , Hung-Ying Kao
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摘要: Promyelocytic leukemia protein (PML) is a tumor suppressor that highly expressed in endothelial cells nonetheless its role cell biology remains elusive. Tumor necrosis factor alpha (TNFα) an important cytokine associated with many inflammation-related diseases. We have previously demonstrated TNFα induces PML accumulation. hypothesized may play signaling pathway. To identify potential target genes and investigate the putative crosstalk between PML’s function cells, we carried out microarray analysis human primary umbilical (HUVECs). found regulate common distinct involved similar spectrum of biological processes, pathways More importantly, required for fine-tuning TNFα-mediated immune inflammatory responses. Furthermore, our data suggest synergistically adhesion by engaging multiple molecular mechanisms. Our functional assays exemplified U937 leukocytes to HUVECs co-regulated signaling. Together, study identified as essential regulator revealing knockdown-mediated effects TNFα-elicited signaling, thereby providing novel insights into cells.
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