[Twice-weekly intermittent chemotherapy during the maintenance phase of the short-course treatment for new patients with pulmonary tuberculosis].

摘要: BACKGROUND AND OBJECTIVE Various types of intermittent chemotherapy regimens have been applied for the treatment tuberculosis worldwide, but, in Japan, any type has not adopted currently as standard tuberculosis. Intermittent a great advantage to facilitate directly observed therapy (DOT). To introduce DOT more extensively we conducted present clinical trial assess effectiveness and safety chemotherapy. PATIENTS METHODS This is non-randomized compare twice-weekly under with daily by self-administration. Newly diagnosed patients pulmonary who completed initial intensified phase 2 months 4 drugs were enrolled. Supervision drug administration was carried out pharmacists cooperated study (Pharmacy DOT). RESULTS Total 385 enrolled this trial, which 135 treated maintenance supervision remaining 250 without (self-administration). Treatment success-rates 97.6% group 95.6% group. Relapse rates after completion course 3.73/ 100 person-year 1.76/100 person-year, respectively. The difference between two groups statistically significant. Adverse events required modification schedule occurred only 0.2% intermittently patients. CONCLUSIONS After successful chemotherapy, during pharmacist effective safe therapy, conveniently accepted pharmacy should be widely introduced Japan.